Sitagliptin is oral antidiabetic agent, prescribed for type 2 diabetes. It helps control blood sugar levels.

Headache, diarrhoea, upper respiratory tract infection, nasopharyngitis. Angioedema, exfoliative dermatitis, hypoglycaemia. Potentially Fatal: Anaphylaxis and/or severe dermatologic reactions such as Stevens-Johnson syndrome.

Concurrent use may increase serum levels of digoxin. Increased risk of hypoglycaemia when used with sulphonylureas.

Type 1 diabetes. Diabetic ketoacidosis.

Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV), resulting in prolonged active incretin levels. Incretin hormones increases insulin synthesis and release from pancreatic β-cells and reduces glucagon secretion from pancreatic α-cells. Reduced glucagon secretion leads to decreased hepatic glucose production. Absorption: Rapid absorption. Bioavailability: About 87%. Distribution: Protein binding: 38%. Metabolism: Not extensively metabolised. Excretion: Elimination half-life: 12 hr. 87% excreted in urine (mainly as unchanged drug) and 13% excreted in faeces.

Discontinue treatment if there are signs of hypersensitivity. Caution when used with sulphonylureas and/or other antidiabetic medications; monitor blood glucose regularly. Renal impairment; dose adjustment may be needed. Children <18 yr. Pregnancy, lactation.

Follow the advice of your doctor before consuming/applying this medicine. For more clarification consult your pharmacist and follow the instructions inside the Januvia 100 mg Tablet pack . The dose and timing of intake/application should be as per your prescription.

Each medicine has different storage requirement pertaining to their physical and chemical properties. Follow the storage instructions of Januvia 100 mg Tablet Tablet as provided on the medicine label. It is advisable to strictly follow Januvia 100 mg Tablet storage instructions to preserve its medicinal value and prevent any decay in its properties or medical potency.

Alcohol can interact with many drugs, and the effects of these interactions can vary. Therefore, it is important to tell your doctor about your alcohol use before taking any medication.

Some drugs can pass into breast milk and be ingested by the baby. It is therefore important to inform your doctor if you are breastfeeding before starting Januvia 100 mg Tablet or any other medicine.

Here is an explanation of why this is important:

1. The amount of drug that passes into breast milk can vary depending on the drug and the dose. Some drugs are excreted in very small amounts, while others can be passed on in higher concentrations.
2. The effects of the drug on the baby can also vary. Some drugs are safe for breastfeeding babies, while others can cause side effects.
3. It is important to talk to your doctor about the risks and benefits of taking any medication while breastfeeding. Your doctor can help you decide if the medication is safe for you and your baby.

Please refer to product insert or consult with your doctor.

The liver is a vital organ that helps to metabolize (break down) drugs. If the liver is not functioning properly, it may not be able to metabolize drugs as effectively. This can lead to a number of problems, including:

1. The drug may not work as well as it should.
2. The drug may build up in the body, leading to toxicity.
3. The drug may interact with other medications, causing unexpected side effects.

If you have any liver problems, it is important to tell your doctor before starting any new medication. Your doctor can help you to choose a medication that is safe for you and that will be metabolized effectively by your liver.

Many drugs are removed from the body through the kidneys. This means that if your kidneys are not working properly, the drugs may build up in your body and cause problems. Additionally, some drugs can actually damage the kidneys, so it is important to be aware of this risk if you have kidney problems.

For these reasons, it is advisable to have your kidney function regularly monitored while you are taking any medication. This will help to ensure that the drugs are not causing any harm to your kidneys. If you have any kidney problems, be sure to tell your doctor so that they can adjust your medication dosage or recommend other medications that are less likely to affect your kidneys.

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