Amikef 250mg Injection
MRP: ₹34.50
Packaging
1 INJECTION
Composition
Amikacin 250mg
Company
Lupin
Substitutes for Amikef 250mg Injection
| Medicine | Company | Price | You Save |
|---|---|---|---|
| Amicip 250mg Injection 2ml | Cipla | ₹9.56 | Save ₹24.94 |
| Ivimicin-250mg Inj. | FDC | ₹31.10 | Save ₹3.40 |
| Omnikacin 250 mg Injection 2ml | Cipla | ₹31.15 | Save ₹3.35 |
| D-cin 250mg Injection 2ml | Daksh Pharma | ₹32.30 | Save ₹2.20 |
| Mikatro 250mg Injection 2ml | Zatropha Pharma | ₹32.32 | Save ₹2.18 |
| Zenikacin 250mg Injection 2ml | Zenicure Labs | ₹32.50 | Save ₹2.00 |
| Amikamac 250mg Injection | Macleods | ₹34.60 | — |
| Mikacin-250mg Inj. | Aristo Pharma | ₹38.70 | — |
| Alfakim 250mg Injection | Sun Pharma | ₹38.85 | — |
| Aminat 250mg Injection 2ml | Natco Pharma | ₹42.00 | — |
| Zycin 250mg Inj. | Zydus Cadila | ₹45.00 | — |
| Erkacin 250mg/2ml Injection | Micro Labs | ₹47.00 | — |
Uses of Amikef 250mg Injection
Amikacin is a broad spectrum anti-biotic . Amikacin is most often used for treating severe, hospital-acquired infections with multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Serratia marcescens and Providencia stuartii are also included in the spectrum.
Side Effects of Amikef 250mg Injection
Tinnitus, vertigo; ataxia and overt deafness. Potentially Fatal: Ototoxicity, nephrotoxicity, neuromuscular blockade.
Drug Interactions
Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together. Potentially Fatal: Increased ototoxic or nephrotoxic effects with other nephrotoxic or ototoxic drugs. Enhanced neuromuscular blockade with neuromuscular blocking drugs. Increased risk of ototoxicity with potent diuretics.
Contraindications
Pregnancy, perforated ear drum, myasthenia gravis, hypersensitivity.
Mechanism of Action
Amikacin binds to 30S ribosomal subunits of susceptible bacteria, thus inhibiting its protein synthesis. Distribution: Detected in body tissues and fluids after inj; crosses the placenta but does not readily penetrate the CSF. Significant amounts penetrate the blood-brain barrier in children with meningitis. Excretion: Via the urine by glomerular filtration (within 24 hr); 2-3 hr (elimination half-life).
Special Precautions
Renal impairment; vertigo, tinnitus. Discontinue if signs of ototoxicity, neurotoxicity or hypersensitivity occurs; lactation. Safety has not been established for treatment period >14 days. Monitor renal function before and during treatment.
How to Use
Take orally with food and water, as directed by your physician.
How to Store
Keep in a cool, dry place away from sunlight and moisture.
Safety Concerns
- Alcohol: Avoid during treatment.
- Breastfeeding: Not recommended.
- Pregnancy: Contraindicated.
- Liver/Kidney: Use with caution.
Content Disclaimer
This content is for educational purposes only. Please consult your doctor before use.
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Written by: SastiMedic Medical Team
Reviewed by: Registered Pharmacist