Arip MT 10mg Tab 10s

Uses of Arip MT 10mg Tab 10s

Aripiprazole is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Aripiprazole is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression).

Side Effects of Arip MT 10mg Tab 10s

Headache, agitation, insomnia, somnolence; dyspepsia, constipation, pain, nausea, vomiting; asthaenia, dizziness, abdominal pain; dry mouth; anxiety, akathisia; orthostatic hypotension; hypertonia, tremor and blurred vision.

Drug Interactions

Drugs that induce CYP3A4 (e.g. carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (e.g. ketoconazole) or CYP2D6 (e.g. quinidine, fluoxetine or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels. Increased CNS depression with ethanol.

Contraindications

Hypersensitivity. Lactation. Children <18 yr.

Mechanism of Action

Aripiprazole acts as a partial agonist at D2 and 5-HT1A receptors and as an antagonist at 5-HT2A receptors. Absorption: Well absorbed from the GI tract. Absolute bioavailability: about 87%. Distribution: Protein binding: about 99%. Metabolism: Mainly in the liver and the pathways involved include dehydrogenation and hydroxylation. Excretion: About 55% excreted in faeces and 25% in urine, mainly in the form of metabolites.

Special Precautions

Patients with known CV diseases (e.g. history of MI, IHD, CCF or conduction abnormalities), cerebrovascular diseases or conditions which would predispose patients to hypotension; Alzheimer's disease and dementia. Caution when operating hazardous machinery, including automobiles when taking aripiprazole. Pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.