Caluran-CP Tablet 30s

Uses of Caluran-CP Tablet 30s

Bicalutamide is used in the treatment of prostate cancer that has spread to other areas of the body. Bicalutamide is used in combination with hormone treatment. Bicalutamide works by blocking the action of male hormones in the prostate, slowing growth of the tumors.

Side Effects of Caluran-CP Tablet 30s

Nausea, vomiting, diarrhoea, asthenia, gynaecomastia, breast tenderness, hot flushes, pruritus, dry skin, alopecia, hirsutism, decreased libido, impotence, weight gain; less commonly hypersensitivity reactions including angioneurotic oedema and urticaria, interstitial lung disease; rarely abdominal pain, CV disorders (including angina, heart failure and arrhythmias), depression, dyspepsia, haematuria, cholestasis, jaundice, thrombocytopenia.

Drug Interactions

Enhances effect of coumarin anticoagulants.

Contraindications

Hypersensitivity. Females, children. Pregnancy, lactation.

Mechanism of Action

Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin, thus preventing the growth of normal and malignant prostatic tissue. Absorption: Well absorbed from the GI tract (oral). Distribution: Protein-binding: 96%. Metabolism: Extensively hepatic by oxidation and glucuronidation. Excretion: Urine and faeces (as metabolites); 6-7 days (elimination half-life of the R-enantiomer).

Special Precautions

Monitor liver function regularly in hepatically impaired patients on prolonged therapy. Monitoring serum levels of Prostate Specific Antigen (PSA) may be useful in evaluating the patient's clincial progress.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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