Clokeran 5mg Tab 30s

Side Effects of Clokeran 5mg Tab 30s

Reversible progressive lymphocytopenia and neutropenia; GI disturbances; hepatotoxicity; skin rashes; peripheral neuropathy; central neurotoxicity including seizures; interstitial pneumonia, pulmonary fibrosis. High doses may produce azoospermia and amenorrhoea. Sterility when given to boys at or before puberty. Potentially Fatal: Severe bone marrow suppression, carcinogenic and human infertility.

Drug Interactions

Impairs immune response to vaccines, possible infection after admin of live vaccines.

Contraindications

Hypersensitivity. Pregnancy and lactation. Porphyria.

Mechanism of Action

Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of the nucleic acid function. Absorption: Rapid and almost complete from the GI tract (oral). Distribution: Protein-binding: Extensive. Metabolism: Extensively hepatic; converted to phenylacetic acid mustard. Excretion: Urine (as metabolites and unchanged drug); 1.5 hr (elimination half-life).

Special Precautions

Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, myelosuppressive drugs or has a depressed baseline leukocyte/platelet count within the previous 4 wk. Increased incidence of acute leukaemias and other secondary malignancies.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.