Clonotril 0.25mg Tab 15s

Side Effects of Clonotril 0.25mg Tab 15s

Drowsiness, fatigue, muscular hypotonia, coordination disturbances, dizziness, vertigo, anorexia, visual disturbances, libido changes. Potentially Fatal: Salivary or bronchial hypersecretion leading to respiratory problems (children). May produce diminished reflexes or coma. Rarely, blood dyscrasias.

Drug Interactions

Carbamazepine, phenobarbitone or phenytoin may accelerate clonazepam metabolism. Potentially Fatal: Increased sedative effect with alcohol, general anaesthetics and TCAs.

Contraindications

Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow angle glaucoma.

Mechanism of Action

Clonazepam is an effective anticonvulsant. It raises the threshold for propagation of seizure activity and prevents generalisation of focal or local activity. Clinically, it improves focal epilepsy and generalised seizures. It is also believed to enhance the activity of GABA, and acts as anxiolytic. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 4 hr. Distribution: Crosses the placenta; enters breast milk. Protein-binding: 86%. Metabolism: Extensively hepatic; converted to 7-aminoclonazepam. Excretion: Urine (as free or conjugated metabolites); 20-40 hr (elimination half-life).

Special Precautions

Neonates, chronic pulmonary insufficiency, hepatic/renal dysfunction, porphyria, elderly; pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.