Cobagen Plus Tablet 10s

Side Effects of Cobagen Plus Tablet 10s

Somnolence, dizziness, ataxia, weakness, paraesthesia, fatigue, headache; nystagmus, diplopia; nausea, vomiting, wt gain, dyspepsia; rhinitis; tremor; leucopenia; altered LFTs; Stevens-Johnson syndrome.

Drug Interactions

Cimetidine may reduce gabapentin clearance. Absorption reduced with antacids.

Contraindications

Hypersensitivity. Lactation.

Mechanism of Action

Gabapentin is structurally related to the neurotransmitter GABA but is neither a GABA agonist nor antagonist. Gabapentin-binding sites have been identified throughout the brain tissues e.g. neocortex and hippocampus. However, the exact mechanism of action is still unknown. Absorption: 50-60% absorbed (oral); peak plasma concentrations after 2 hr. Distribution: Widely distributed; enters breast milk. Protein-binding: Minimal. Metabolism: Poor. Excretion: Urine and faeces; 5-7 hr (elimination half-life).

Special Precautions

Discontinuation or transfer from other antiepileptics, history of psychotic illness; renal impairment; pregnancy. Gradual withdrawal over at least 7 days to prevent an increase in seizure frequency.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.