Cobese-120mg Cap

Uses of Cobese-120mg Cap

Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body. Orlistat is used to aid in weight loss, or to help reduce the risk of regaining weight already lost.

Side Effects of Cobese-120mg Cap

Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort. Potentially Fatal: Anaphylaxis; angioedema.

Drug Interactions

May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.

Contraindications

Chronic malabsorption syndrome. Cholestasis. Lactation.

Mechanism of Action

Orlistat is a reversible gastric and pancreatic lipase inhibitor. It exerts antiobesity effects by limiting the absorption of dietary fats through inhibition of triglyceride hydrolysis. It does not exert appetite suppressant effects. Onset: 24-48 hr. Duration: 48-72 hr. Absorption: Minimally absorbed (oral). Metabolism: Metabolised to inactive metabolites within the GI wall. Excretion: Mainly via faeces (83% as unchanged drug).

Special Precautions

Distribute daily intake of fat over 3 main meals. Fat-soluble vitamins supplements may be required during long-term therapy. Discontinue use if 5% body wt loss is not achieved during the first 12 wk. History of hyperoxaluria or calcium oxalate nephrolithiasis. DM. Pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.