Combisure 125 Inhaler

Uses of Combisure 125 Inhaler

Fluticasone is used in asthma to prevent the inflammation and excess mucus formation, and therefore help prevent asthma attacks and shortness of breath. Formoterol is a bronchodilator and helps in improving breathing . This combination is used in various bronchospam conditions like COPD , chronic bronchitis , asthma , allergic rhinitis etc.

Side Effects of Combisure 125 Inhaler

Tremor, headache, tiredness, restlessness, dizziness, dry mouth, palpitation, tachycardia, muscle cramps, nausea.

Drug Interactions

Concomitant treatment with xanthine derivatives, steroids or diuretics may potentiate a possible hypokalaemic effect of β-agonists. Increased susceptibility to cardiac arrhythmias in patients treated with digitalis. Concomitant use with quinidine, disopyramide, procainamide, phenothiazines, antihistamines, MAOI or TCAs can prolong the QT-interval and increase the risk of ventricular arrhythmias. L-dopa, L-thyroxine, oxytocin and alcohol can impair cardiac tolerance towards β2-sympathomimetics. β-adrenergic blockers can inhibit the effect of formoterol. Increased risk of arrhythmias in patients receiving concomitant anaesthesia with halogenated hydrocarbons.

Contraindications

Hypersensitivity.

Mechanism of Action

Formoterol relaxes the bronchial smooth muscle by selectively acting on β2-receptors with minimal effect on heart rate. It has a long-acting effect.

Special Precautions

Thyrotoxicosis; severe CV disorders e.g. ischaemic heart disease, tachyarrhythmias or severe heart burn; prolonged QT-interval. DM; pregnancy; lactation; children <5 yr; do not initiate or increase the dose during an exacerbation. May produce paradoxical bronchospasm.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.