D-Void Nasal Spray

Uses of D-Void Nasal Spray

Desmopressin is used for the treatment of excessive urination especially in patients who suffer from night time bed-wetting . Also indicated in diabetes insipidus .

Side Effects of D-Void Nasal Spray

Nausea, transient headache; nasal congestion, rhinitis; flushing; mild abdominal cramps; epistaxis; sore throat, cough, stuffiness; allergic reactions, inj site pain, erythema, swelling, BP changes and thrombotic events in predisposed individuals. Potentially Fatal: Water intoxication and dilutional hyponatraemia.

Drug Interactions

Drugs that may potentiate antidiuretic effect of desmopressin: chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or TCAs. Drugs that may decrease antidiuretic effect of desmopressin: lithium, heparin, demeclocycline, noradrenaline, and alcohol. Caution when using with other vasopressors.

Contraindications

Hypersensitivity. Impaired renal function (CrCl <50 ml/min). Decompensated cardiac failure with ongoing diuretic treatment.

Mechanism of Action

Desmopressin increases the cellular permeability of the collecting ducts causing an increased water reabsorption, smooth muscle constriction. It also stimulates factor VIII and plasminogen activation activity in blood. Absorption: Absorbed from the nasal mucosa (intranasal), absorbed in sufficient amounts from the GI tract to produce therapeutic effects at high doses (oral). Metabolism: Largely destroyed in the GI tract. Excretion: Elimination T1/2 (biphasic): 8 min (initial phase), 75 min (terminal phase).

Special Precautions

Not to be used in the treatment of Type IIb von Willebrand's disease and nephrogenic diabetes insipidus. Fluid intake restricted to a min and only to satisfy thirst for 8 hr after admin (particularly in the very young and the elderly). Nasal route avoided in patients with nasal mucosal diseases. Caution in CV diseases, oedema states, impairment, hypertension, elderly, cystic fibrosis, fluid and electrolyte imbalance, thrombotic disease; infants and young children. Inj not recommended for infants <3 mth for bleeding disorders. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.