Depakote-250mg Tab 15s

Side Effects of Depakote-250mg Tab 15s

Behavioural/mood changes; hyperammonaemia; pancreatitis, thrombocytopenia. Abdominal cramps, anorexia, diarrhoea, hair loss, indigestion, nausea and vomiting; tremor; unusual weight loss or gain. Potentially Fatal: Hepatic failure, pancreatitis.

Drug Interactions

Felbamate increases valproate levels. Phenytoin, phenobarbitone and carbamazepine lower valproate levels. Increased risk of hepatotoxity with hepatotoxic drugs. Potentially Fatal: Potentiates action of CNS depressants (barbiturates, primidone) and alcohol.

Contraindications

Hepatic disease or severe hepatic impairment; porphyria. Pregnancy.

Mechanism of Action

ivalproex sodium dissociates to the valproate ion in the GI tract. It is thought to work by increasing brain concentrations of GABA which may also play an important role in the prevention of migraine attacks. Distribution: Plasma protein binding ranges from 10-18.5%. Metabolism: Almost entirely by liver.

Special Precautions

Children <2 yr; congenital metabolic disorders; organic brain disease or severe seizure disorders; HIV infection; renal impairment; lactation. Monitor liver function before and during the 1st 6 mth of therapy. Monitor platelet function, signs of pancreatitis and SLE. Gradual withdrawal of valproate. May impair ability to drive or operate machinery. Increased risk of hyperammonaemic encephalopathy in patients with urea cycle disorders.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.