Estramin 140mg Capsule 10s

Side Effects of Estramin 140mg Capsule 10s

Gynaecomastia, fluid retention and CV effects, GI disturbances, hepatic dysfunction, loss of libido, hypersensitivity reactions and occasionally leucopaenia and thrombocytopaenia.

Drug Interactions

NA

Contraindications

Active thrombophloebitis or thromboembolic disorders. Hypersensitivity.

Mechanism of Action

Estramustine is a combination of oestradiol and normustine which readily dephosphorylates during absorption to give estramustine, oestrone analog, oestradiol and oestrone. The oestrodiols released facilitate the uptake of the alkylating agent into the prostate cancer cells which inhibits microtubule assembly. Its effects are weaker than most alkylating agents and oestradiols.

Special Precautions

Diabetes mellitus, CHF, epilepsy, hypertension, migraine, hepatic impairment. Increased risk of thrombosis and myocardial infarction. May exacerbate fluid retention. May affect the metabolism of calcium and phosphorus. Monitor hepatic function and bilirubin level regularly and for at least 2 mth after treatment withdrawal. Pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.