Floricot Tab

Side Effects of Floricot Tab

Hypertension, sodium and water retention, potassium loss, dizziness, itching, skin rash, headache, convulsions, CHF, muscle weakness, hyperglycaemia, HPA and growth suppression, peptic ulcer, cataracts, raised intraocular pressure and reduced visual acuity.

Drug Interactions

May decrease salicylate levels. Anticholinesterase effects are antagonised. Decreased effects with rifampin, barbiturates, hydantoins and phenytoin. Oral contraceptives or ritonavir may increase the plasma concentrations of fludrocortisone. Increased potassium loss with potassium-depleting drugs e.g. thiazides, furosemide or amphotericin B. Increased risk of GI bleeding or ulceration with NSAIDs. May alter efficacy of anticoagulants when used concurrently.

Contraindications

Hypersensitivity. Hyperalbuminaemia; hypertension, systemic fungal infections.

Mechanism of Action

Fludrocortisone promotes reabsorption of sodium and urinary excretion of potassium and hydrogen ions from renal distal tubules. Absorption: Rapid and complete (oral). Peak plasma concentrations after 1.7 hr. Distribution: Protein-binding: 42%. Metabolism: Hepatic. Excretion: Elimination half-life: >3.5 hr (plasma); 18-36 hr (biological).

Special Precautions

Addison's disease, fluid retention and hypokalaemia. Pregnancy, lactation, children and elderly.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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