Flutopic Skin Ointment

Uses of Flutopic Skin Ointment

Fluticasone prevents the release of inflammatory substances in the body. As nasal spray of inhalers Fluticasone improves breathing in patients suffering from nasal congestion, sneezing, runny nose, and itchy or watery eyes

Side Effects of Flutopic Skin Ointment

Topical: Pruritus, hypertrichosis, dryness, numbness of fingers, burning, eruptions, hypopigmentation, allergic contact dermatitis, secondary infection, skin atrophy, Cushing's syndrome, reversible HPA-axis suppression. Inhalation: Oropharyngeal candidiasis, pharyngitis, dysphoria, cough, rhinitis, nasal congestion and headache. Systemic absorption may be seen when applied to large areas, when skin is broken or under occlusive dressings. Potentially Fatal: Suppression of immune system.

Drug Interactions

May lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors such as ritonavir.

Contraindications

Hypersensitivity. Acne vulgaris, rosacea, perioral dermatitis, skin atrophy; hypersensitivity. Primary cutaneous viral infections (e.g. herpes simplex, chicken pox), perianal and genital pruritus, primary fungal or bacterial skin infections. Inhalation: Status asthmaticus.

Mechanism of Action

Fluticasone utilises a fluorocarbothioate ester linkage at the C17 position. It has potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically. Absorption: Poorly absorbed from the GI tract (oral). Distribution: Protein-binding: 91%. Metabolism: Extensively hepatic; converted to 17β-carboxylic acid. Excretion: Faeces (as unchanged drug and metabolites), urine (as metabolites).

Special Precautions

Children, pregnancy, lactation, concomitant skin infections. Concomitant skin/lung/systemic infections. Advised to rinse mouth with water every time after inhalation. Application to large areas, broken skin or under occlusive dressings.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.