Folnew Capsule 10s

Side Effects of Folnew Capsule 10s

GI disturbances, hypersensitivity reactions; bronchospasm.

Drug Interactions

Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.

Contraindications

Undiagnosed megaloblastic anaemia; pernicious, aplastic or normocytic anaemias.

Mechanism of Action

Folic acid is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. It is also essential in the synthesis and maintenance of nucleoprotein in erythropoesis. It also promotes WBC and platelet production in folate-deficiency anaemia. Onset: Peak effect: Oral: 0.5-1 hr. Absorption: Rapidly absorbed mainly from the duodenum and jejunum. Distribution: Extensively bound to plasma protein. Principal site of storage is the liver. It is also concentrated in the CSF and enters the breast milk. Metabolism: Undergoes conversion in the plasma and liver to the metabolically active 5-methyltetrahydrofolate. Excretion: Via urine (as unchanged drug and metabolites). Removed by haemodialysis.

Special Precautions

Treatment resistance may occur in patients with depressed haematopoiesis, alcoholism, deficiencies of other vitamins. Neonates.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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