Geriflo D Cap

Uses of Geriflo D Cap

Tamsulosin and Dutasteride combination is used in benign Benign Prostatic Hyperplasia for improving urination . Due to enlarged prostate , the neck of urinary bladder gets obstructed and urination becomes difficult and painful. They help in relaxing the bladder muscles thus opening the mouth of urinary bladder and easing urination .

Side Effects of Geriflo D Cap

Impotence; decreased libido; ejaculation disorders; breast tenderness and enlargement.

Drug Interactions

Concurrent use with CYP3A4 inhibitors such as diltiazem and verapamil may increase serum levels of dutasteride.

Contraindications

Severe liver impairment; pregnant women, children, adolescent.

Mechanism of Action

Dutasteride has antiandrogenic properties. It inhibits 5α-reductase, thus preventing the conversion of testosterone to 5α-dihydrotestosterone which is the main androgen involved in causing prostate enlargement. Absorption: Absorbed from the GI tract, reaching peak serum concentration in 1-3 hr. Bioavailability: About 60%. Distribution: Highly bound to plasma proteins. Metabolism: Metabolised by CYP3A4 and CYP3A5. Excretion: Mainly excreted as metabolites in faeces. Elimination half-life: About 3-5 wk.

Special Precautions

Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling dutasteride capsules. Advisable to exclude other causes of benign prostatic hypertrophy (e.g. prostate cancer, infection) before initiating therapy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.