Glez-5mgTab

Side Effects of Glez-5mgTab

GI upsets, diarrhoea, nausea; allergic skin reactions, leucopenia, thrombocytopenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopenia. Potentially Fatal: Hypoglycaemia in presence of renal or hepatic damage and alcohol.

Drug Interactions

Decreased effect with β-blockers, cholestyramine, hydantoins, thiazide diuretics and urinary alkalinizers. Increased hypoglycaemic effects with H2 antagonists, anticoagulants, androgens, cimetidine, salicylates, TCAs, fluconazole, gemfibrozil, ketoconazole, NSAIDs, pioglitazone, sulfonamides, probenecid, MAOIs, methyldopa, digitalis glycosides and urinary acidifiers.

Contraindications

Hypersensitivity. Type 1 DM; ketoacidosis; severe renal or hepatic insufficiency. Pregnancy, lactation.

Mechanism of Action

Glipizide stimulates insulin release from pancreatic β-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at target sites. Duration: 24 hr. Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr. Distribution: Protein-binding: Extensive. Metabolism: Hepatic. Excretion: Urine (as inactive metabolites); faeces; 2-4 hr (elimination half-life).

Special Precautions

Hypoglycaemia, stress, elderly. Thyroid impairment; moderate hepatic or renal impairment. Monitor blood glucose concentration.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.