Grandem-1mg Inj.

Side Effects of Grandem-1mg Inj.

Headache; sensation of flushing; constipation; hypersensitivity reactions; chest pain; CV disturbances; dizziness; transient visual disturbances. Rarely, liver disorders; development of seizures; extrapyramidal reactions.

Drug Interactions

Phenobarbital may induce metabolism of granisetron.

Contraindications

Hypersensitivity.

Mechanism of Action

Granisetron is a selective 5-HT3-receptor antagonist with little or no affinity for other serotonin receptors. It blocks serotonin in the chemoreceptor zone. Duration: 24 hr. Absorption: Rapidly absorbed after oral admin. Oral bioavailability: About 60%. Distribution: Protein binding: About 65%. Metabolism: Hepatically metabolised, mainly by N-demethylation. Excretion: IV admin: Elimination half-life: 4-5 hr in healthy subjects; 9-12 hr in cancer patients.

Special Precautions

Subacute intestinal obstruction or ileus. Moderate to severe hepatic impairment. Congenital long QT syndrome or other risk factors for QT prolongation (e.g. electrolyte abnormalities and cumulative high-dose anthracycline therapy). Pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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