Karplat 450 mg Injection

Uses of Karplat 450 mg Injection

Carboplatin is a chemotherapy drug . It is used in the treatment of various kinds of cancer like ovarian carcinoma, lung, head and neck cancers as well as endometrial, esophageal, bladder, breast and cervical; central nervous system or germ cell tumors; osteogenic sarcoma, and as preparation for a stem cell or bone marrow transplan

Side Effects of Karplat 450 mg Injection

Thrombocytopenia, neutropenia, leukopenia, anaemia; nausea, vomiting, central neurotoxicity, peripheral neuropathies, ototoxicity; elevation of ALT, AST, blood urea and bilirubin levels, electrolyte disturbances; alopecia; asthenia, pain; cardiac failure, embolism and cerebrovascular accidents may occur; mucositis. Potentially Fatal: Bone marrow suppression and anaphylactic reactions.

Drug Interactions

Increased risk of ototoxicity when used with aminoglycosides.

Contraindications

Previous allergy; pregnancy, lactation; allergy to other platinum compounds; severe bone marrow depression; significant bleeding, aluminium containing needles and IV sets.

Mechanism of Action

Carboplatin is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function. Excretion: About 70% of a dose is excreted unchanged in the urine. Terminal half-life: 1.5-6 hr.

Special Precautions

Neonates; diminished renal function; neurotoxicity; liver function impairment.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.