Keflor Suspension

Side Effects of Keflor Suspension

Allergic reactions; diarrhoea, nausea, vomiting; candidiasis, eosinophilia; elevated transaminases. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Drug Interactions

Probenecid slows tubular excretion. Potentially Fatal: May enhance nephrotoxicity of aminoglycosides and furosemide. Bleeding may occur if taken with anticoagulants.

Contraindications

Known hypersensitivity to cephalosporins.

Mechanism of Action

Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae. Absorption: Well absorbed from the GIT (oral); rate but not extent of absorption is altered by food. Distribution: Widely distributed; crosses the placenta and enters breast milk (low concentrations). Protein-binding: 25% Excretion: Via the urine by the kidneys within 8 hrs (as 85% unchanged); the greater part of the dose within 2 hrs. Elimination half-life: 0.5-1 hr, slightly prolonged in renal impairment. May be removed by haemodialysis.

Special Precautions

Severe renal impairment; history of allergy to penicillin; pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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