Kool-IT Tab 10s

Uses of Kool-IT Tab 10s

Rabeprazole and Itopride combination is used in the treatment of irritable bowel syndrome. This medicine improves gastric motility , gastro-duodenal coordination and thus helps in smooth emptying of stomach .

Side Effects of Kool-IT Tab 10s

Headache, diarrhoea, dizziness, rash. Potentially Fatal: Anaphylaxis, agranulocytosis.

Drug Interactions

Rabeprazole increase elimination T1/2 of digoxin, decreases effects with aminoglutethimide, carbamazepine, phenytoin and rifampin and reduces absorption of ketoconazole and itraconazole. Anticholinergic agents reduces the action of itopride.

Contraindications

Hypersensitivity; lactation.

Mechanism of Action

Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell. Itopride increases acetylcholine (ACh) concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher ACh increases GI peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.

Special Precautions

Itopride should be used with caution because it enhances the action of acetylcholine Rabeprazole should be used with caution in patients with severe hepatic impairment. Pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.