Lenalid 5mg Cap 30s

Side Effects of Lenalid 5mg Cap 30s

HTN, diarrhoea, upper respiratory tract infections, thrombocytopenia, leukopenia, pancytopenia, agranulocytosis, headache, alopecia, dry skin, eczema, erythema multiforme, hypokalaemia, weight loss, asthenia, anxiety, paraesthesia, synovitis, joint disorder, peripheral neuropathy, mild hyperlipidaemia, interstitial lung disease, vasculitis. Potentially Fatal: Hepatotoxicity, sepsis, Stevens-Johnson syndrome, toxic epidermal necrolysis, pancreatitis.

Drug Interactions

Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs may increase the risk of hepatotoxicity. Rifampicin increases serum levels of the active metabolite. Potentially Fatal: May enhance the adverse effects of live vaccines.

Contraindications

Hepatic impairment, moderate and severe renal impairment, compromised immune function including bone marrow dysplasia or severe uncontrolled infection, severe hypoproteinaemia; concurrent vaccination w/ live vaccines. Pregnancy and lactation.

Mechanism of Action

Leflunomide is an immunomodulating agent and DMARD. It inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resulting in antiproliferative and anti-inflammatory effects. Absorption: Bioavailability: Approx 82-95%. Time to peak plasma concentration (active metabolite): 6-12 hr. Distribution: Volume of distribution: 0.13 L/kg. Plasma protein binding (active metabolite): 99% (mainly albumin). Metabolism: Rapidly converted to active metabolite A77 1726 in GI mucosa and the liver. Excretion: Via urine (approx 43% as glucuronides) and faeces (approx 48%). Elimination half-life (active metabolite): Approx 14-18 days.

Special Precautions

Mild renal impairment. Patient w/ history of TB due to the possibility of reactivation of the infection. Monitoring Parameters Monitor BP and liver enzyme values prior to initiation and periodically during therapy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.