Letroz 2.5mg Tab 5s

Uses of Letroz 2.5mg Tab 5s

Letrozole is used in the treatment of hormonally-responsive breast cancer after surgery.

Side Effects of Letroz 2.5mg Tab 5s

Hot flushes, arthralgia, nausea, vomiting, fatigue, dizziness, headache, dyspepsia, constipation, diarrhoea, anorexia, alopoecia, increased sweating, rash, peripheral oedema, osteoporosis, musculoskeletal pain, vaginal irritation. Potentially Fatal: Thromboembolic events.

Drug Interactions

Plasma levels reduced by tamoxifen.

Contraindications

Premenopausal women and children; hypersensitivity.

Mechanism of Action

Letrozole competitively binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgen to oestrogen, leading to inhibition of the enzyme and a significant reduction in plasma oestrogen levels. Absorption: Rapidly and completely absorbed from the GI tract. Distribution: Weakly bound to plasma proteins and has a large volume of distribution of about 1.9 l/kg. Metabolism: Slow hepatic metabolism to inactive metabolites. Excretion: Via urine (6% as unchanged drug); elimination half life of about 2 days.

Special Precautions

Severe renal impairment; severe hepatic impairment; osteoporosis. Caution when driving or operating machinery.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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