Lorinol-10mg Tab

Side Effects of Lorinol-10mg Tab

Fatigue, giddiness, dizziness, dry mouth, headache, nausea, somnolence.

Drug Interactions

Plasma concentrations increased by ketoconazole, cimetidine, nefazodone, erythromycin and possibly other inhibitors of CYP3A4.

Contraindications

Pregnancy, lactation, children <2 yr.

Mechanism of Action

Loratadine is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1 -receptors on effector cells. Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1 hr. Absorption delayed by the presence of food. Distribution: Enters breast milk, does not cross the blood-brain barrier. Protein-binding: 98%. Metabolism: Extensively hepatic; converted to descarboethoxyloratadine (desloratadine). Excretion: Via urine and faeces (as metabolites);elimination half-life 8.4 hr (loratadine) and 28 hr (desloratadine).

Special Precautions

Severe hepatic damage, epilepsy, renal insufficiency.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.