Substitutes for Lostat-50 Tab
| Medicine | Company | Price | You Save |
|---|---|---|---|
| Giftan 50mg Tablet 10s | Systopic | ₹29.50 | Save ₹12.50 |
| Zilos-50mg Tab | FDC | ₹33.25 | Save ₹8.75 |
| Actilop-50mg Tab | Active HC | ₹39.00 | Save ₹3.00 |
| Icosar 50 Tablet 10s | Icon Life Sciences | ₹46.60 | — |
| Losanorm-50 Tab | Ipca Labs | ₹47.70 | — |
| Lot 50 mg Tablet 10s | Abbott India | ₹48.51 | — |
| Zaart 50 mg Tablet 10s | CIPLA | ₹49.75 | — |
| Losatrust 50 mg Tablet 10s | Centaur Labs | ₹49.77 | — |
| Lara-50mg Tab | Alkem Labs | ₹49.83 | — |
| Zosartan 50mg Tablet 10s | Zaneka Healthcare Pvt Ltd | ₹51.92 | — |
| Angizaar 50mg Tablet 10s | Micro Labs | ₹52.80 | — |
| Alsartan-50 Tab | Aristo Pharma | ₹53.00 | — |
| Covance-50 Tab | Sun Pharma | ₹54.40 | — |
| Tozaar 50mg Tablet 10s | Torrent Pharma | ₹57.60 | — |
| Revas-50mg Tab 10s | Alembic Pharma | ₹59.65 | — |
| Repace 50mg TabLET 10s | Sun Pharma | ₹59.75 | — |
| Cosart 50 mg Tablet 10s | Cipla | ₹64.49 | — |
| Nusar-50mg Tab | Emcure Pharma | ₹73.00 | — |
| Omnitan-50 Tab | Macleods | ₹75.00 | — |
| Losartas 50mg Tablet 10s | INTAS | ₹79.00 | — |
| Losium-50 Tab | Cadila Pharma | ₹85.09 | — |
| Losar-50mg Tab | Unichem | ₹97.95 | — |
Uses of Lostat-50 Tab
Antihypertensive. It is used in the management of high blood pressure.
Side Effects of Lostat-50 Tab
Headache, dizziness, back pain, myalgia, respiratory tract disorders, asthenia/fatigue, first dose hypotension, rash, angioedema, neutropenia, GI disturbances, transient elevation of liver enzymes, impaired renal function, taste disturbances and hyperkalaemia.
Drug Interactions
Hypotensive effect of losartan potentiated by diuretics and other antihypertensives. Risk of hyperkalaemia increases with concomitant ACE inhibitors, ciclosporin, potassium-sparing diuretics and K supplements. Hypotensive effect may be antagonised and increased risk of renal impairment when used with NSAIDs. Potentially Fatal: Risk of lithium toxicity with losartan use.
Contraindications
Pregnancy, lactation; children with CrCl <30 ml/min/1.73m2.
Mechanism of Action
Losartan is an angiotensin II receptor antagonist. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors. Absorption: Readily absorbed from GI tract with peak plasma concentrations of losartan after around 1 hr and its active metabolite after 3-4 hr. Distribution: 98% plasma protein bound. Metabolism: Hepatic metabolism principally by isoenzymes CYP3A4 and 2C9. Excretion: Excreted in faeces and urine as metabolites and unchanged drug. Terminal elimination half life of 2 hr (losartan) and 6-9 hr (active metabolite).
Special Precautions
Volume-depleted patients including patients on diuretics and salt restriction; renal artery stenosis; elderly; renal or hepatic impairment. Monitor serum-potassium concentration.
How to Use
Take orally with food and water, as directed by your physician.
How to Store
Keep in a cool, dry place away from sunlight and moisture.
Safety Concerns
- Alcohol: Avoid during treatment.
- Breastfeeding: Not recommended.
- Pregnancy: Contraindicated.
- Liver/Kidney: Use with caution.
Content Disclaimer
This content is for educational purposes only. Please consult your doctor before use.
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Written by: SastiMedic Medical Team
Reviewed by: Registered Pharmacist