Luprex Tablet 10s

Side Effects of Luprex Tablet 10s

Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.

Drug Interactions

May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.

Contraindications

Hypersensitivity. Porphyria.

Mechanism of Action

Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth. Absorption: Plasma concentrations peak after 2 hr (oral); reduced if taken after food. Bioavailability: about 50%. Distribution: Widely distributed into body tissues and fluids. Protein-binding: 96% at trough concentrations. Metabolism: Small amounts are metabolised in the liver. Excretion: Mainly via the faeces as unchanged drug and metabolites, via the urine (7-12%) and the lungs (15%). Elimination half-life: 8-13 hr. May be prolonged in renal and hepatic impairment, children.

Special Precautions

Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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