Macphyllin 100mg Cap

Uses of Macphyllin 100mg Cap

Acebrophylline, is prescribed by medical practitioners as a bronchodilator for the treatment of bronchial asthma and COPD in adults. Acebrophylline alter mucus gel secretion phase by lowering viscosity and increasing the serous gel phase. By augmenting ciliary motility, Acebrophylline increases the mucociliary clearance.

Side Effects of Macphyllin 100mg Cap

Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs. Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.

Drug Interactions

May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.

Contraindications

Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.

Mechanism of Action

Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr. Distribution: Protein-binding: 99%. Excretion: Urine (as hydroxymetabolites); 4 hr (elimination half-life).

Special Precautions

Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.