Macrozide-1500 Tab

Side Effects of Macrozide-1500 Tab

Hepatotoxicity (hepatomegaly, splenomegaly and jaundice may develop and in rare case fulminating acute yellow atrophy and death). Anorexia, nausea, vomiting, arthralgia, malaise, fever, hyperuricaemia, abnormal LFT, skin rashes. Potentially Fatal: Severe liver damage, fulminant hepatitis.

Drug Interactions

Excretion may be blocked by probenecid.

Contraindications

Hypersensitivity; existing liver disease; acute gout or hyperuricaemia. Porphyria. Pregnancy and lactation.

Mechanism of Action

Pyrazinamide has bactericidal action against M. tuberculosis in acid environment present in macrophages and inflammed tissue. Together with rifampicin provides greatest sterilising action with reduction in relapse rate. Reduces tubular secretion of uric acid. Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. Distribution: Body fluids and tissues (wide), CSF, enters breast milk. Metabolism: Hepatic; hydrolysed to pyrazinoic acid (active) then hydroxylated to 5-hydroxypyrazinoic acid (major excretory product). Excretion: Via urine by glomerular filtration (70% as metabolites, 4-14% as unchanged); 9-10 hr (elimination half-life), removed by dialysis.

Special Precautions

Diabetes, renal failure, history of gout, children. Monitor liver function and serum uric acid regularly.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.