Matabac 1gm Inj.

Side Effects of Matabac 1gm Inj.

GI disturbances; hypersensitivity. Potentially Fatal: Stevens-Johnson syndrome.

Drug Interactions

Probenecid may increase the serum concentrations of sulbactam.

Contraindications

Hypersensitivity.

Mechanism of Action

Sulbactam, a penicillanic acid sulfone with β-lactamase inhibitory properties has weak antibacterial activity, but is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases. It has a similar spectrum of β-lactamase inhibition to clavulanic acid, although it is less potent. It enhances the activity of penicillins and cephalosporins. It is usually given with ampicillin to increase the antimicrobial spectrum; may also be used with cefoperazone. Absorption: Poorly absorbed from the GI tract. Distribution: Distributed into breast milk. Protein binding: 38%. Excretion: Half-life elimination: 1-1.3 hr. About 75-85% is excreted unchanged in the urine within 8 hr.

Special Precautions

Hepatic disease, biliary obstruction, ingestion of alcohol, pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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