Natclovir 500mg Injection

Uses of Natclovir 500mg Injection

Ganciclovir is an antiviral medication that is used to treat cytomegalovirus (CMV) infections. CMV is a virus that can cause serious infections in people with weakened immune systems, such as people with AIDS or people who have received organ transplants. Ganciclovir can help to prevent CMV infections from developing, and it can also help to treat CMV infections that have already developed.

Side Effects of Natclovir 500mg Injection

Haematolgical disturbances; marrow depression; GI disturbances; fever, rash and abnormal LFTs; irritation and phlebitis at inj site. Less frequent: CV, CNS, metabolic, musculoskeletal, respiratory, urogenital, ocular effects, cutaneous symptoms and increased serum-creatinine and BUN concentration. Potential risk of testicular effects and female fertility.

Drug Interactions

Renal clearance reduced by probenecid; imipenem cilastatin (generalised seizures); zidovudine; didanosine; additive toxic effects with myelosuppressants; oral mycophenolate mofetil.

Contraindications

Hypersensitivity; absolute neutrophil count <500 cells/mm3; platelet count <25,000/mm3; pregnancy, lactation. Not to be used as a bolus inj.

Mechanism of Action

Ganciclovir is a synthetic guanine nucleoside analogue with activity against cytomegalovirus (CMV). It competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase, thus inhibiting viral DNA synthesis. Absorption: Poor absorption after oral admin. Distribution: Widely distributed to body tissues and fluids after IV admin. Excretion: Excreted unchanged in the urine mainly via glomerular filtration and active tubular secretion. Elimination half-life: 2.5-4.5 hr after IV admin; increased in renal impairment.

Special Precautions

Renal impairment; preexisting cytopenias or history of cytopenic reactions to drugs; child; contraceptive precautions to be followed during and at least 90 days thereafter; care in administering only into veins with good blood flow. Avoid contact with the skin and eyes. Maintain adequate hydration during infusion. Monitor WBC and platelet counts regularly during treatment. Eye examinations should be conducted at least once every 4-6 wk during treatment for CMV retinitis.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.