Pacifol Injection 10ml

Side Effects of Pacifol Injection 10ml

Involuntary muscle movements; nausea, vomiting, headache, fever; pain, burning or stinging at inj site. Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis.

Drug Interactions

Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.

Contraindications

Electroconvulsive therapy, obstetrics. Sedation in children ≤16 yr. Pregnancy, lactation.

Mechanism of Action

Propofol is a short-acting anaesthetic given for induction and maintenance of general anaesthesia. Onset: 30 sec. Duration: 3-10 min. Distribution: Extensively redistributed from brain to other tissues; crosses the placenta and enters breast milk. Protein-binding: 95% Metabolism: Extensively hepatic; converted to water-soluble sulfate and glucuronide conjugates. Excretion: Urine (as metabolites); faeces. Elimination half-life:40 min (initial); 4-7 hr (terminal).

Special Precautions

Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.