Peakhale FB 100 Rotacaps

Side Effects of Peakhale FB 100 Rotacaps

Headache, nasopharyngitis, upper respiratory tract infections, stomach discomfort, vomiting, oral candidiasis, back pain, nasal congestion, sinusitis.

Drug Interactions

Concomitant admin with CYP3A4 inhibitor e.g. itraconazole, clarithromycin, erythromycin may inhibit the metabolism of budesonide. Concurrent use with nonpotassium-sparing diuretics may lead to ECG changes and/or hypokalaemia.

Contraindications

Primary treatment of status asthmaticus or other acute episodes of asthma.

Mechanism of Action

Budesonide is a corticosteroid that has mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein syntheis, decreasing the migration of polymorphonuclear leucocytes/fibroblasts and reversing capillary permeability. Formoterol fumarate is a selective β2-adrenergic agonist. It causes bronchodilation by catalysing the conversion of adenosine triphosphate to cyclic-3', 5'-adenosine monophosphate (cyclic AMP) resulting in bronchial smooth muscle relaxation. Absorption: Budesonide: Orally inhaled budesonide is rapidly absorbed in the lungs. Formoterol: Rapidly absorbed after inhalation. Distribution: Budesonide: 85-90% bound to plasma proteins. Metabolism: Formoterol: Primary metabolism pathway is via direct glucuronidation and O-demethylation followed by conjugation to inactive metabolites. Excretion: Budesonide: Excreted in urine and faeces as metabolites. Formoterol: Excreted mainly in urine and some in faces.

Special Precautions

May increase the risk of death in patients. Not to be used for transferring patients from systemic corticosteroid treatment. May produce paradoxical bronchospasm which is life-threatening. Caution when used in patients with CV diseases, especially coronary insufficiency, cardiac arrhythmias and hypertension. Chronic use may further decrease bone mineral content when used in patients with advanced age, osteoporosis, poor nutrition, sedentary lifestyle or tobacco use. May reduce growth velocity when used in paediatric patients. Caution when used in patients with active or quiescent tuberculosis infection of the respiratory tract, untreated systemic fungal, bacterial, viral or parasitic infections, or ocular herpes simplex. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.