Ursocol 600mg Tab 10s

Uses of Ursocol 600mg Tab 10s

Ursodeoxycholic Acid used to dissolve gallstones made of cholesterol and to treat a condition called primary biliary cirrhosis.

Side Effects of Ursocol 600mg Tab 10s

Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.

Drug Interactions

Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.

Contraindications

Calcified and pigment gallstones, radio opaque gallstones. Nonfunctioning gall bladders; chronic liver and peptic ulcer disease. Inflammatory disease of colon and small intestine. Pregnancy.

Mechanism of Action

Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol. Absorption: Rapidly and completely absorbed from the GI tract. Distribution: Protein binding: 96-98%. Undergoes enterohepatic recycling. Metabolism: Partly conjugated in the liver before being excreted into the bile. Free and conjugated forms undergo 7a-dehydroxylation to lithocholic acid under the influence of gut bactera. Some are reabsorbed and then further conjugated and sulfated by the liver. Excretion: Faeces.

Special Precautions

50% of successfully treated patients will develop further gallstones within 10 yr. Lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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