Zabpro 500 mg Tablet 60s

Uses of Zabpro 500 mg Tablet 60s

Abiraterone is used in the treatment of metastatic castration-resistant prostate cancer.

Side Effects of Zabpro 500 mg Tablet 60s

Common side effects of abirateron include :
1. Urinary tract infection
2. Hypokalemia
3. Hypertension
4. Diarrhoea .
5. Increased liver enzymes
6. Increased cholesterol level in blood
7. Joint swelling
8. High Blood pressure
9. Decreased white blood cells and Anemia

Drug Interactions

Abiraterone is a CYP3A4 substrate and hence should not be administered in patients concurrently on strong CYP3A4 inhibitors or inducers.Likewise it inhibits CYP1A2, CYP2C9 and CYP3A4 and hence should not be given to patients concurrently being treated with substrates of any of these enzymes that have a narrow therapeutic index.

Contraindications

Patients with severe baseline hepatic , impairment , Mineralocorticoid excess , cardiovascular disease, including heart failure and hypertension, uncorrected hypokalaemia , adrenocorticoid insufficiency and Hepatotoxicity that may result from treatment with abiraterone

Mechanism of Action

Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17-α-hydroxy derivatives by its 17 α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its C17,20 lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of testosterone.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.