Zefu-500 Tab

Uses of Zefu-500 Tab

Cefuroxime is a cephalosporin antibiotic. Cefuroxime is used in the treatment of various bacterial infections. Cefuroxime is used in infections of respiratory tract infections like pharyngitis, otitis media, sinusitis, and bronchitis.

Side Effects of Zefu-500 Tab

Large doses can cause cerebral irritation and convulsions; nausea, vomiting, diarrhoea, GI disturbances; erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis. Potentially Fatal: Anaphylaxis, nephrotoxicity, pseudomembranous colitis.

Drug Interactions

Probenecid decreases renal clearance of cefuroxime. Potentially Fatal: Nephrotoxicity with aminoglycosides and furosemide.

Contraindications

Hypersensitivity to cephalosporins.

Mechanism of Action

Cefuroxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Absorbed from the GI tract with peak plasma concentrations after 2-3 hr (oral); may be enhanced by the presence of food. Distribution: Pleural and synovial fluid, sputum, bone and aqueous fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk. Protein-binding: Up to 50%. Metabolism: Rapidly hydrolysed (intestinal mucosa and blood). Excretion: Via the urine by glomerular filtration and renal tubular secretion (as unchanged); via bile (small amounts); 70 min (elimination half-life); prolonged in neonates and renal impairment.

Special Precautions

Severe renal impairment; pregnancy, lactation; hypersensitivity to penicillins.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.