Zenidime 1gm Injection

Uses of Zenidime 1gm Injection

Ceftazidime is an anti-biotic and is used in teh treatment of bacterial infections. Ceftazidime is a potent anti biotic and is generally used in serious infections or life threatening infections due to gram positive bacteria.

Side Effects of Zenidime 1gm Injection

Hypersensitivity, dizziness, diarrhoea, nausea, vomiting, renal impairment, rash, erythema multiforme, thrombocytopaenia, superinfection, phloebitis and thrombophloebitis at the site of injection. Potentially Fatal: Anaphylactic reactions, nephrotoxicity, pseudomembranous colitis.

Drug Interactions

Probenecid may decrease ceftazidime elimination time. Potentially Fatal: Furosemide and aminoglycosides may increase nephrotoxicity.

Contraindications

Hypersensitivity to cephalosporins.

Mechanism of Action

Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Peak plasma concentrations after 1 hr (IM), 5 min (IV bolus). Distribution: Widely distributed in body tissues and fluids; CSF (therapeutic concentrations when meninges are inflamed). Crosses the placenta and enters breast milk. Protein-binding: 10% Excretion: Mainly by the kidneys via the urine by glomerular filtration (80-90% as unchanged drug within 24 hr); passively excreted in bile but only a small proportion is eliminated. Clearance enhanced in cystic fibrosis; 2 hr (elimination half-life), prolonged in neonates and renal impairment.

Special Precautions

History of penicillin allergy; severe renal impairment; pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.