Zivator-1gm Injection

Side Effects of Zivator-1gm Injection

GI effects, injection-site reactions, raised platelet count; less frequently dry mouth, taste disturbances; hypotension, chest pain, oedema, pharyngeal discomfort, dyspnoea, dizziness, sleep disturbances, confusion, asthenia, seizures, vaginitis, raised glucose; headache; hypersensitivity reactions; antibiotic-associated colitis; dysphagia, cholecystitis; liver disorder; arrhythmia; increase in blood pressure; syncope; nasal congestion; cough; wheezing; CNS effects; pelvic peritonitis; renal impairment; muscle cramp, scleral disorder; blood disorders, hypoglycaemia; electrolyte disturbances. Local site reactions such as pain and thrombophlebitis may occur. Potentially Fatal: Pseudomembranous colitis, Stevens-Johnson syndrome.

Drug Interactions

Valproate; oestrogens. Renal excretion inhibited by probenecid.

Contraindications

Hypersensitivity; lactation.

Mechanism of Action

Ertapenem acts similarly to penicillins by bacterial cell wall inhibition. It is active against many gram-negative and aerobic and anaerobic organisms. It is stable to hydrolysis by β-lactamases. Distribution: >90% bound to plasma proteins. Distributes into breast milk. Metabolism: Part metabolised by hydrolysis of its β-lactam ring by dehydropeptidase I to an open-ringed metabolite. Excretion: About 80% of a dose is excreted in the urine as both unchanged drug and metabolite and 10% is excreted in faeces.

Special Precautions

Hypersensitivity to penicillins, cephalosporins or other β-lactams (possibility of cross-sensitivity). Renal impairment; CNS disorders e.g. epilepsy. Pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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