Zynagel 400mg Tab 10s

Uses of Zynagel 400mg Tab 10s

Sevelamer is used to treat high phosphate levels in patients with kidney failure on dialysis .

Side Effects of Zynagel 400mg Tab 10s

Faecal impaction, hypercalcaemia, oesophageal and dysphagia tablet retention, diarrhoea, flatulence, ileus, peritonitis, diverticulitis, dyspepsia, intestinal obstruction and perforation, nausea, vomiting, constipation, pruritus, rash.

Drug Interactions

May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.

Contraindications

Patients w/ hypophosphataemia or bowel obstruction.

Mechanism of Action

Sevelamer, a polymeric compound, acts by binding to phosphate molecules in the gut, limiting its absorption and thus lowering serum phosphate levels w/o altering Ca, Al, or bicarbonate levels. Onset: After 1-2 wk. Absorption: Not systematically absorbed. Excretion: Via faeces.

Special Precautions

Patients w/ dysphagia, swallowing disorders, severe GI motility disorders, active inflammatory bowel disease or major GI tract surgery. Pregnancy and lactation. Monitoring Parameters Monitor BP; serum levels of Ca, Cl and bicarbonate; reduced vit D, E, K and folic acid levels. Monitor for signs and symptoms of peritonitis in patients undergoing peritoneal dialysis.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.