Actidrox-125 Syrup

Side Effects of Actidrox-125 Syrup

Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially candida. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Drug Interactions

Prothrombin time prolonged; bleeding may occur when taken with anticoagulants. Decreased elimination with probenecid.

Contraindications

Hypersensitivity to cephalosporins.

Mechanism of Action

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1.5-2 hr. Distribution: Body tissues and fluids (wide); crosses the placenta and enters breast milk. Protein-binding: 20%. Excretion: Via urine by glomerular filtration and tubular secretion (90% as unchanged); 1.5 hr (elimination half-life), prolonged in renal impairment. Removed by dialysis.

Special Precautions

Impaired renal function; pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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