Amtas E Tablet 15s

Uses of Amtas E Tablet 15s

Antihypertensive

Side Effects of Amtas E Tablet 15s

Angioneurotic oedema, nausea, headache, cough, dizziness, fatigue, palpitations, chest pain, flushing, rash; increases in BUN, serum K & creatinine levels may occur; neutropaenia. Potentially Fatal: NA.

Drug Interactions

Indometacin and other NSAIDs may blunt antihypertensive effect. Diuretics enhance antihypertensive effect. Potentially Fatal: Increases lithium levels & may cause lithium toxicity: Hyperkalaemia with K & K sparing diuretics. Risk of bone marrow suppression due to enalapril increased with concomitant use of immunosuppressives.

Contraindications

Hypersensitivity to either component. History of angioedema related to previous exposure to ACE inhibitor. Pregnancy.

Mechanism of Action

Amlodipine is a 1,4-dihydropyridine-derivative calcium-channel blocker. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active ACE inhibitor.

Special Precautions

Lactation. Renal and hepatic disease, congestive heart failure; concomitant K supplements & potassium-conserving diuretics, hypovolaemic shock, diuretic therapy; periodic blood count monitoring to preclude neutropaenia or agranulocytosis.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.