Apixabid 5mg Tablet 10s

Uses of Apixabid 5mg Tablet 10s

ELIQUIS in India contains APIXABAN which is prescribed in following conditions: 1. To lower the risk of stroke and embolism in patients with nonvalvular atrial fibrillation. Deep vein thrombosis (DVT) prophylaxis. 2. DVT's may lead to pulmonary embolism (PE) in knee or hip replacement surgery patients. 3. Treatment of both DVT and PE. 4. To reduce the risk of recurring DVT and PE after initial therapy.

Side Effects of Apixabid 5mg Tablet 10s

Apixaban like other oral anticoagulants can increase the risk of bleeding in patients and may cause serious, potentially fatal, bleeding. Concurrent use of Apixaban with drugs affecting hemostasis (e.g. other anticoagulants, heparin, aspirin and other antiplatelet drugs, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs) can further increase the risk of bleeding.

Drug Interactions

1. Strong dual inhibitors of CYP3A4 and P-gp increase blood levels of apixaban. Reduce dose or avoid coadministration. 2. Simultaneous use of strong dual inducers of CYP3A4 and P-gp reduces blood levels of apixaban: Avoid concomitant use.

Contraindications

1. Active pathological bleeding 2. Severe hypersensitivity to ELIQUIS

Mechanism of Action

Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. Apixaban has no direct effect on platelet aggregation, but by inhibiting factor Xa, it indirectly decreases platelet formation induced by thrombin.

Special Precautions

1. ELIQUIS can cause serious, potentially fatal bleeding. Promptly evaluate signs and symptoms of blood loss. (5.2) 2. Prosthetic heart valves: ELIQUIS use not recommended.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.