Arbitus 250mg Tablet 120s
MRP: ₹39,500.00
Packaging
TAB
Composition
Abirateron 250mg
Company
Dr. Reddy
Substitutes for Arbitus 250mg Tablet 120s
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| Abatitor 250mg Tablet 120s | Torrent Pharma | ₹39,900.00 | — |
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| Alkeprost 250mg Tablet 120s | Alkem Labs | ₹45,000.00 | — |
Uses of Arbitus 250mg Tablet 120s
Abiraterone is used in the treatment of metastatic castration-resistant prostate cancer.
Side Effects of Arbitus 250mg Tablet 120s
Side effects of Abirateron may include Urinary tract infection,Hypokalemia, Hypertension Diarrhoea etc.
Drug Interactions
Abiraterone is a CYP3A4 substrate and hence should not be administered in patients concurrently on strong CYP3A4 inhibitors or inducers.Likewise it inhibits CYP1A2, CYP2C9 and CYP3A4 and hence should not be given to patients concurrently being treated with substrates of any of these enzymes that have a narrow therapeutic index.
Contraindications
Patients with severe baseline hepatic , impairment , Mineralocorticoid excess , cardiovascular disease, including heart failure and hypertension, uncorrected hypokalaemia , adrenocorticoid insufficiency and Hepatotoxicity that may result from treatment with abiraterone
Mechanism of Action
Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17-α-hydroxy derivatives by its 17 α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its C17,20 lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of testosterone.
How to Use
Take orally with food and water, as directed by your physician.
How to Store
Keep in a cool, dry place away from sunlight and moisture.
Safety Concerns
- Alcohol: Avoid during treatment.
- Breastfeeding: Not recommended.
- Pregnancy: Contraindicated.
- Liver/Kidney: Use with caution.
Content Disclaimer
This content is for educational purposes only. Please consult your doctor before use.
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Written by: SastiMedic Medical Team
Reviewed by: Registered Pharmacist