Atarap 4mg Tablets 10s

Side Effects of Atarap 4mg Tablets 10s

Extrapyramidal reactions, insomnia, drowsiness, dizziness. ECG changes, dry mouth, constipation, urinary difficulty and blurred vision. Potentially Fatal: Neuroleptic malignant syndrome.

Drug Interactions

Propranolol and cimetidine decrease hepatic metabolism and increase efficacy and toxicity. Concurrent use with SSRIs may increase risk of extrapyramidal adverse effects and potentially fatal torsades de pointes arrhythmias. Potentially Fatal: Potentiates other CNS depressants eg, alcohol and benzodiazepines. Increased risk of arrhythmias due to prolonged QT interval with TCAs, terfenadine, astemizole, antimalarial and cisapride. Concurrent use with inhibitors of CYP3A4 or CYP2D6 may lead to increased plasma concentrations leading to cardiac arrhythmias. Imatinib may also raise the plasma concentrations of pimozide. Avoid use with drugs that cause electrolyte disturbances eg, diuretics.

Contraindications

Prolonged QT interval, family history of congenital QT prolongation, history of cardiac arrhythmias.

Mechanism of Action

Pimozide is a long-acting antipsychotic structurally similar to butyrophenones which blocks dopaminergic receptors in the CNS. It also exhibits some calcium-blocking activity. Absorption: >50% absorbed (oral); peak plasma levels after 4-12 hr. Metabolism: Extensively hepatic via N-dealkylation. Excretion: Urine and faeces (as unchanged drug and metabolites).

Special Precautions

Parkinson's syndrome; epilepsy, pregnancy, lactation; hepatic or renal impairment; monitor ECG before and during treatment; review the need for continuing treatment if repolarisation changes occur. Monitor cardiac function in patients taking >16 mg daily. Electrolytes disturbances such as hypomagnesaemia or hypokalaemia may increase risk of cardiotoxicity.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.