Atpure-25mg Tab

Uses of Atpure-25mg Tab

Atenolol is a beta blocker and is used in the treatment of high blood pressure .

Side Effects of Atpure-25mg Tab

Bradycardia, hypotension, chest pain, oedema, heart failure. Dizziness, sweating, fatigue, insomnia, lethargy, confusion, mental impairment, depression, headache, nightmares. Constipation, diarrhoea, nausea, impotence, cold extremities.

Drug Interactions

Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive w/ Ca channel blockers, hydralazine, methyldopa. Increased risk of bradycardia and heart block w/ verapamil and diltiazem. May decrease hypotensive effects w/ NSAIDs (e.g. indometacin). Enhanced bradycardic effect w/ disopyramide, amiodarone or digitalis glycosides. May exacerbate rebound HTN upon discontinuance of clonidine treatment.

Contraindications

Sick sinus syndrome, severe bradycardia, 2nd or 3rd degree AV block, uncompensated cardiac failure, severe asthma or COPD, cardiogenic shock, untreated pheochromocytoma, metabolic acidosis, severe peripheral circulatory disease.

Mechanism of Action

Atenolol is a competitive cardioselective β1-blocker and does not have effect on β2-receptors except in high doses. It reduces resting and exercise-induced heart rate as well as myocardial contractility. Onset: 2-4 hr (oral). Duration: 12-24 hr. Absorption: Rapidly but incompletely absorbed from the GI tract (approx 50%). Time to peak plasma concentration: 2-4 hr (oral). Distribution: Enters breast milk, crosses the placenta and blood-brain barrier (small amounts). Plasma protein binding: 6-16%. Metabolism: Undergoes minimal hepatic metabolism. Excretion: Via urine (40% as unchanged drug); faeces (50%). Plasma half-life: Approx 6-7 hr.

Special Precautions

Patients w/ inadequate cardiac function, well-compensated heart failure, bronchospastic disease, DM, hyperthyroidism. Patients undergoing major surgery involving general anaesth. May mask symptoms of hypoglycaemia and hyperthyroidism. Avoid abrupt withdrawal as it may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias or may precipitate thyroid storm. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor ECG, heart rate and BP.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.