Bencid-500mg Tab

Side Effects of Bencid-500mg Tab

Seizures (overdosage), headache, anorexia; nausea, vomiting, urinary frequency, sore gums, dizziness, dermatitis, uric acid nephrolithiasis and pruritus. Potentially Fatal: Hepatic necrosis, aplastic anaemia, anaphylaxis.

Drug Interactions

Pyrazinamide and salicylates antagonize uricosuric effects of probenecid. May reduce clearance of methotrexate, ganciclovir and aciclovir. Probenecid may increase the plasma concentrations of penicillins or β-lactams. Potentially Fatal: Reduced renal clearance of sulphonylurea antidiabetic and ketorolac.

Contraindications

Hypersensitivity, acute gout attack, history of uric acid nephrolithiasis, blood dyscrasias, childn <2 yr, as an antibacterial adjunct in patients with known renal impairment.

Mechanism of Action

Probenecid increases excretion of uric acid by competitively blocking its reabsorption at the proximal convoluted tubule thus lowering serum uric acid levels and eventually reducing urate deposits in the tissues. It also causes plasma levels of weak organic acids (eg, penicillins and most cephalosporins) to increase by competitively inhibiting their renal tubular secretion.

Special Precautions

Pregnancy and lactation; renal impairment, history of peptic ulcer, G6PD deficient individuals. Adequate fluid intake is recommended especially during the first few mth of treatment.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.