Betaferon Injection

Uses of Betaferon Injection

Interferon beta is a cytokine in the interferon family used to treat multiple sclerosis (MS).

Side Effects of Betaferon Injection

Insomnia, nervousness, depression, dizziness, anxiety, emotional lability; alopecia, pruritus, rash; hot flushes; GI disturbances; blood dyscrasia; inj site reactions; myalgia, arthralgia, pain, paraesthesia; flu-like symptoms; upper respiratory tract infection; chest pain, arrhythmia, MI; hypersensitivity reaction; blurred or loss of vision; hepatomegaly, liver tenderness.

Drug Interactions

Enhanced myelosuppression with other myelosuppressive drugs. Drugs metabolised via the CYP450 pathway (monitor for changes in pharmacologic or adverse effects of concomitant drug).

Contraindications

Hypersensitivity. Hepatic decompensation, autoimmune hepatitis.

Mechanism of Action

Interferon alfacon-1 has antiviral, antiproliferative and immune-regulating effects. It induces gene transcription, inhibits cellular growth, alters the state of cellular differentiation, interferes with oncogene expression, alters cell-surface antigen expression, increases phagocytic activity of macrophages and augments cytotoxicity of lymphocytes for target cells.

Special Precautions

History of severe psychiatric disorders (monitor for signs of depression). Preexisting or history of cardiac disease. Perform periodic ophthalmologic exam in patients with preexisting ophthalmologic disorders (e.g. diabetic or hypertensive retinopathy). Autoimmune disorders. History of endocrine disorders. Abnormally low peripheral blood cell counts or concurrent myelosuppressive therapy. Transplantation or chronically immunosuppressed patients. Monitor haematological and thyroid functions before therapy, 2 wk after initiation and periodically thereafter. Elderly. Children (not recommended). Pregnancy, lactation. Withhold dose in patients who experience a severe adverse reaction, stop or decraese treatment if the reaction does not become tolerable.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.