Carbomox-250mg Cap 6s

Uses of Carbomox-250mg Cap 6s

Amoxicillin is a penicillin antibiotic that fights bacteria. Amoxicillin is used to treat many different types of infection caused by bacteria, such as tonsillitis, bronchitis, pneumonia, gonorrhea, and infections of the ear, nose, throat, skin, or urinary tract.

Side Effects of Carbomox-250mg Cap 6s

Headache, nausea, dizziness, vomiting, diarrhoea, GI discomfort/ bleeding, black hairy tongue, maculopapular rash, urticaria, eosinophilia, hemolytic anemia, thrombocytopenia. Potentially Fatal: Anaphylaxis, pseudomembranous colitis, acute cytoloytic hepatitis and Stevens-Johnson syndrome.

Drug Interactions

Live oral typhoid vaccine should not be given 3 days before or 3 days after amoxicillin admin as immune response may be attenuated. Amoxicillin increases the anticoagulant response of coumarins. Amoxicillin may reduce OC pill absorption leading to breakthrough bleeding or pregnancy. Amoxicillin reduces the renal clearance of methotrexate and pemetrexate. Amoxicillin level significantly reduced when given with or 2 hr after acacia admin.

Contraindications

Allergy to penicillins, pregnancy.

Mechanism of Action

Amoxicillin inhibits the final transpeptidation of peptidoglycan synthesis in bacterial cell walls. Hence, cell wall synthesis is inhibited and results in bacterial lysis. Carbocisteine is a mucolytic. It penetrates into lung tissue and respiratory mucus. Reduces viscosity of bronchial secretions and allows greater penetration of antibacterial drug. Expectoration of the mucus is facilitated. Absorption: Amoxicillin: Rapidly and almost completely absorbed from the GI tract; peak plasma concentration (oral): 1-2 hr. Carbocisteine: Rapidly and well absorbed from GI tract; peak plasma concentration (oral): 2 hr. Distribution: Amoxicillin: Protein binding: 17-20 %; Widely distributed to body fluid and bone, CSF (small concentrations except when meninges are inflamed). Carbocisteine: Lungs. Metabolism: Amoxicillin: Partially metabolised to penicilloic acid. Carbocisteine: Metabolised via acetylation, decarboxylation and sulfoxidation. Excretion: Amoxicillin: Via urine: 60% as unchanged drug. Elimination half-life: Adults: 0.7-1.4hr, CrCl<10 ml/min: 7-21 hr; infants & children: 1-2 hr. Carbocisteine: Via urine: Unchanged and as metabolites.

Special Precautions

History of peptic ulcer, severe renal impairment. Infectious mononucleosis and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.