Cardem-30mg Tab

Uses of Cardem-30mg Tab

Diltiazem is used in the treatment of high blood pressure and angina pectoris (chest pain). Diltiazem comes under the class of calcium channel blocker and reduces blood pressure relaxing the blood vessels.

Side Effects of Cardem-30mg Tab

Headache, ankle oedema, hypotension, dizziness, fatigue, flushing, nausea, GI discomfort, gingival hyperplasia, rashes, erythema multiforme, exfoliative dermatitis, photosensitivity, occasionally hepatitis. Potentially Fatal: AV block, bradycardia, asystole, sinus arrest.

Drug Interactions

Increases serum theophylline levels. Cimetidine may increase plasma concentrations of diltiazem. Concurrent use may lead to increased blood ciclosporin levels. Potentially Fatal: Increased depression of cardiac conduction with amiodarone, β-blockers, digoxin and mefloquine. May potentiate risk of bradycardia and conduction disturbance of propranolol and risk of neurotoxicity of lithium.

Contraindications

Sick-sinus syndrome; 2nd or 3rd ° AV block; porphyria. Severe congestive cardiac failure; marked bradycardia. Pregnancy and lactation.

Mechanism of Action

Diltiazem relaxes coronary vascular smooth muscles by inhibiting influx of calcium ions during depolarisation of the vascular smooth muscles and myocardium. It increases myocardial O2 delivery in patients with vasospastic angina and inhibits cardiac conduction, particularly at the SA and AV nodes. Absorption: Rapidly and almost completely absorbed from the GI tract (oral). Distribution: Enters breast milk. Protein-binding: 80%. Metabolism: Hepatic: Extensive first-pass effect; yields desacetyldiltiazem (posseses 25-50% of the activity of the parent drug). Excretion: Via urine (2-4% as unchanged and metabolites), via bile (remaining metabolites); 3-5 hr (elimination half-life).

Special Precautions

Elderly. Hepatic or renal impairment; impaired left ventricular function; prolonged AV periods; DM; hypotension. Avoid abrupt withdrawal and long-term use. Patients with sick-sinus syndrome, preexisting AV block, bradycardia and those taking beta-blockers or digitalis are at risk of developing AV block, bradycardia, asystole or sinus arrest.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.