Combizol F Syrup 30ml

Side Effects of Combizol F Syrup 30ml

Nausea, vomiting, heartburn, constipation, diarrhoea, abdominal cramping, anorexia; headache, dizziness; depression, insomnia; phototoxicity; rash, fever, arthralgia; elevated liver enzymes, urea and creatinine. Eosinophilia, neutropenia, thrombocytopenia and anaemia; hyperhidris; tendon rupture; QT prolongation. Potentially Fatal: Anaphylaxis, acute renal failure, seizures.

Drug Interactions

Antacids reduce absorption from GI tract. Probenecid reduces urinary excretion of norfloxacin. Norfloxacin may increase concentration of clozapine, ropinirole, tacrine, tizanidine. Severe hypoglycaemia has occured rarely with glyburide. Increased risk of CNS stimulation and seizures with NSAIDs. Potentially Fatal: Raises theophylline and ciclosporin levels. Effects of warfarin potentiated. Risk of QT prolongation and torsades de pointes with class I and III antiarrythmics, cisapride, erythromycin, antipsychotics, TCAs.

Contraindications

Hypersensitivity to quinolones; children <18 yr. Lactation

Mechanism of Action

Norfloxacin inhibits the action of DNA gyrase in DNA replication, transcription, repair, recombination and transposition. Absorption: 30-40% absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr. May be delayed by the presence of food. Distribution: Genitourinary tract, placenta, bile (high concentrations). Protein-binding: 14%. Metabolism: Hepatic; converted to several metabolites with antibacterial activity. Excretion: Via urine by glomerular filtration and tubular secretion within 24 hr (30% as unchanged); via faeces (30%); 4 hr (elimination half-life); may be prolonged in renal impairment.

Special Precautions

Renal impairment; history of CNS disorders; myasthaenia gravis. Pregnancy. QT prolongation; discontinue if signs of neuropathy occur.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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