Dacarzine 200mg Inj.

Side Effects of Dacarzine 200mg Inj.

Leucopenia, thrombocytopenia, anorexia, nausea, diarrhoea, vomiting; flu-like syndrome, myalgia, malaise, facial flushing, paraesthesia, skin reactions, rashes; alopoecia, photosensitivity reactions. Potentially Fatal: Myelosuppression; hepatotoxicity, anaphylaxis.

Drug Interactions

Impairs immune response to vaccines; possible infection after admin of live vaccines. Effect increased by CYP1A2 inhibitors e.g. amiodarone, ciprofloxacin, fluvoxamine, ketoconazole, lomefloxacin, ofloxacin and rofecoxib. Effect decreased by CYP1A2 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital and rifampicin.

Contraindications

Bone marrow suppression; hypersensitivity.

Mechanism of Action

The exact mechanism of action is still unclear but it appears to form methylcarbonium ions that attack nucleophilic groups by attaching to the 7-position of guanine on DNA. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis. Absorption: Poorly absorbed from the GI tract (oral). Distribution: Crosses the blood-brain barrier; localised in the liver. Protein-binding: 5%. Metabolism: Extensively hepatic. Excretion: Urine (as unchanged drug). Elimination half-life: 20 min (initial), 5 hr (terminal).

Special Precautions

Hepatic or renal impairment. Pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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